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Mostrando ítems 1-15 de 15

A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes

Herrero, P.; Bondía Company, Jorge; Oliver, N.; Georgiou, P. (Taylor & Francis, 2017)

[EN] Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 ...
Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study

Liberos Mascarell, Alejandro; Bueno-Orovio, Alfonso; Rodrigo Bort, Miguel; Ravens, Ursula; Hernández-Romero, Ismael; Fernández-Avilés, Francisco; Guillem Sánchez, María Salud; Rodríguez López, Blanca; Climent, Andreu M. (Elsevier, 2016-12)

BACKGROUND Atrial remodeling as a result of long-standing persistent atrial fibrillation (AF) induces substrate modifications that lead to different perpetuation mechanisms than in paroxysmal AF and a reduction in the ...
Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities

Charon, Justine; Olendraite, Ingrida; Forgia, Marco; Chong, Li Chuin; Hillary, Luke S.; Roux, Simon; Kupczok, Anne; Debat, Humberto; Sakaguchi, Shoichi; Tahzima, Rachid; Nakagawa, So; Babaian, Artem; Abroi, Aare; Bejerman, Nicolas; Ben Mansour, Karima; Cervera, A. (Frontiers Media, 2024-04-04)

[EN] Improved RNA virus understanding is critical to studying animal and plant health, and environmental processes. However, the continuous and rapid RNA virus evolution makes their identification and characterization ...
Data-driven discovery of changes in clinical code usage over time: a case-study on changes in cardiovascular disease recording in two English electronic health records databases (2001-2015)

Rockenschaub, Patrick; Nguyen, Vincent; Aldridge, Robert W.; Acosta, Dionisio; Garcia-Gomez, Juan M; Sáez Silvestre, Carlos (BMJ, 2020-02)

[EN] Objectives To demonstrate how data-driven variability methods can be used to identify changes in disease recording in two English electronic health records databases between 2001 and 2015. Design Repeated cross-sectional ...
El Páncreas Artificial: Control Automático de Infusión de Insulina en Diabetes Mellitus Tipo 1

Bondía Company, Jorge; Vehí, J.; Palerm, C. C.; Herrero, P. (Universitat Politècnica de València, 2010-04-09)

[ES] La diabetes mellitus tipo 1 es una enfermedad crónica que afecta aproximadamente a 30 millones de personas en el mundo y se caracteriza por niveles de concentración de glucosa en sangre elevados producidos por una ...
Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator - in silico evaluation under intra- day variability

Herrero, P.; Bondía Company, Jorge; Adewuji, O.; Pesl, P.; El-Sharkawy, M.; Reddy, M.; Toumazou, C.; Oliver, N.; Georgiou, P. (Elsevier, 2017)

[EN] Background and Objective: Current prototypes of closed-loop systems for glucose control in type 1 diabetes mellitus, also referred to as artificial pancreas systems, require a pre-meal insulin bolus to compensate for ...
FaST-LMM for two-way Epistasis tests on high performance clusters

Martínez, Héctor; Barrachina, Sergio; Castillo, Maribel; Quintana Ortí, Enrique Salvador; Rambla de Argila, Jordi; Farre, Xavier; Navarro, Arcadi (Mary Ann Liebert, 2018-08)

[EN] We introduce a version of the epistasis test in FaST-LMM for clusters of multithreaded processors. This new software maintains the sensitivity of the original FaST-LMM while delivering acceleration that is close to ...
Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

Ferreiros-Vidal, Isabel; Carroll, Thomas; Zhang, Tianyi; Lagani, Vincenzo; Ramirez, Ricardo N.; Ing-Simmons, Elizabeth; Gomez-Valades, Alicia G.; Cooper, Lee; Liang, Ziwei; Papoutsoglou, Georgios; Dharmalingam, Gopuraja; Guo, Ya; Tarazona, Sonia; Fernandes, Sunjay J.; Noori, Peri (Public Library of Science, 2019-04)

[EN] The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically ...
ICTV Virus Taxonomy Profile: Avsunviroidae

Di Serio, Francesco; Li, S.F.; Matousek, J.; Owens, R.A.; Pallás Benet, Vicente; Randles, J.W.; Sano, T.; Verhoeven, J.; Vidalakis, G.; Flores Pedauye, Ricardo (Microbiology Society, 2018-05)

[EN] Members of the family Avsunviroidae have a single-stranded circular RNA genome that adopts a rod-like or branched conformation and can form, in the strands of either polarity, hammerhead ribozymes involved in their ...
ICTV Virus Taxonomy Profile: Ophioviridae

Garcia, M.L; Dal Bo, Elena; da Graca, John V.; Gago Zachert, Selma Persida; Hammond, J; Moreno, Pedro; Natsuaki, T; Pallás Benet, Vicente; Navarro Bohigues, José Antonio; Reyes, Carina; Luna, Gabriel Robles; Sasaya, Takahide; Tzanetakis, Loannis E.; Vaira, Anna Maria; Verbeek, Martin (Microbiology Society, 2017)

[EN] The Ophioviridae is a family of filamentous plant viruses, with single-stranded negative, and possibly ambisense, RNA genomes of 11.3-12.5 kb divided into 3-4 segments, each encapsidated separately. Virions are naked ...
ICTV Virus Taxonomy Profile: Pospiviroidae

Di Serio, Francesco; Owens, Robert A.; Li, Shi-Fang; Matousek, Jaroslav; Pallás Benet, Vicente; Randles, John W.; Sano, Teruo; Verhoeven, Jacobus Th. J.; Vidalakis, Georgios; FLORES PEDAUYE, RICARDO (Microbiology Society, 2021)

[EN] Members of the family Pospiviroidae have single-stranded circular RNA genomes that adopt a rod-like or a quasi-rod-like conformation. These genomes contain a central conserved region that is involved in replication ...
Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

Ortiz-Ramón, Rafael; Valdés Hernández, Maria del C.; González-Castro, Victor; Makin, Stephen; Armitage, Paul A.; Aribisala, Benjamin S.; Bastin, Mark E.; Deary, Ian J.; Wardlaw, Joanna M.; Moratal, David (Elsevier, 2019-06)

[EN] Background: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually ...
Improved Aures tonality metric for complex sounds

Estreder-Campos, Juan; Piñero, Gema; Diego Antón, María; Ramo, Jussi; Välimäki, Vesa (Elsevier, 2023-03-15)

[EN] This paper proposes improvements to the Aures' tonality metric, which can be used for estimating the frequency masking of complex sounds. The perception of tonality has been extensively studied in simple sounds, such ...
Method for automatic adjustment of an insulin bolus calculator: In silico robustness evaluation under intra-day variability

Herrero, Pau; Pesl, Peter; Bondía Company, Jorge; Reddy, Monika; Oliver, Nick; Georgiou, Pantelis; Toumazou, Christofer (Elsevier, 2015-04)

Background and objective: Insulin bolus calculators are simple decision support software tools incorporated in most commercially available insulin pumps and some capillary blood glucose meters. Although their clinical ...
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men

Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R.; Virtue, Samuel; Watson, Laura P. E.; Murgatroyd, Peter R.; Ambler, Graeme K.; Vidal Puig, Santiago; Chatterjee, Krishna V.; Vidal-Puig, Antonio (American Society for Nutrition, 2017)

[EN] Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold ...