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Browsing by Subject "DNA damage"

Now showing items 1-13 of 13

Caracterización molecular de modelos celulares asociados a tres genotipos de la Disqueratosis Congénita

Fuster Martí, Vanessa (Universitat Politècnica de València, 2016-09-05)

[ES] La Disqueratosis congénita (DC, ORPHA1775) está catalogada como una enfermedad rara, con una prevalencia 1 en 1.000.000. Se trata de una enfermedad progeroide que presenta una clásica triada de signos mococutaneos: ...
EFFECTS OF GLUTATHIONE LEVELS ON DNA DAMAGE

Spis, Marta (Universitat Politècnica de València, 2011-09-21)

Free radicals cause DNA damage known as double-strand breaks (DSBs). In response to these DSBs phosphorylation of histone H2AX occurs. yH2AX foci are trademarks of DSBs. We evaluated the levels of yH2AX in relation to ...
eIF2 kinases mediate beta-lapachone toxicity in yeast and human cancer cells

MENACHO MARQUEZ, Mauricio Ariel; Rodríguez Hernández, Carlos Javier; Villaronga, Ángeles; Pérez Valle, Jorge; Gadea Vacas, José; Belandia, Borja; Murguía Ibáñez, José Ramón (Taylor & Francis, 2015-03)

[EN] In this work we focus on the problem of approximating multiple roots of nonlinear equations. Multiple roots appear in some applications such as the compression of band-limited signals and the multipactor effect in ...
Generation of the Thymine Triplet State by Through-Bond Energy Transfer

Miró, Paula; Gomez-Mendoza, Miguel; SASTRE NAVARRO, GERMAN IGNACIO; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa (John Wiley & Sons, 2019-05-17)

[EN] Benzophenone (BP) and drugs containing the BP chromophore, such as the non-steroidal anti-inflammatory drug ketoprofen, have been widely reported as DNA photo-sensitizers through triplet-triplet energy transfer (TTET). ...
Mechanistic Studies on the Photochemical Formation and Cleavage of Oxetanes Derived from Pyrimidine Bases

Blasco Brusola, Alejandro (Universitat Politècnica de València, 2021-04-13)

[ES] La luz solar puede producir daños en el ADN por absorción directa de luz UVB, o por fotosensibilización tras la absorción de luz UVA por parte de fármacos, que pueden actuar como fotosensibilizadores (PS). La benzofenona ...
Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley-VCH Verlag, 2013-06-17)

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These ...
Photosensitized Thymine Dimerization via Delocalized Triplet Excited States

Miró Richart, Paula; Lhiaubet, Virginie Lyria; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (Wiley, 2015-11-16)

A new mechanism of photosensitized formation of thymine (Thy) dimers is proposed, which involves generation of a delocalized triplet excited state as the key step. This is supported by chemical evidence obtained by combining ...
Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium

Rodríguez Muñiz, Gemma María; Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley-VCH Verlag, 2012-06-25)

DNA damage: The reactivity of HO. with silylated 2¿-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported ...
Repair of a Dimeric Azetidine Related to the Thymine-Cytosine (6-4) Photoproduct by Electron Transfer Photoreduction

Fraga Timiraos, Ana Belén; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley, 2016-05-10)

[EN] Photolyases are intriguing enzymes that take advantage of sunlight to restore lesions like cyclobutane pyrimidine dimers or (6-4) photoproducts. This work focused on the photoreductive process responsible for splitting ...
Sodium tungstate modulates ATM function upon DNA damage

Rodríguez Hernández, Carlos Javier; Llorens Agost, M.; Calbó, J.; Murguía, Jose R.; Guinovart, J.J. (Wiley, 2013-05-21)

[EN] Both radiotherapy and most effective chemotherapeutic agents induce different types of DNA damage. Here we show that tungstate modulates cell response to DNA damaging agents. Cells treated with tungstate were more ...
The (6-4) Dimeric Lesion as a DNA Photosensitizer

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2016)

[EN] Based on our previous investigations into the photophysical properties of the 5-methyl-2-pyrimidone (Pyo) chromophore, we now extend our studies to the photobehavior of the dimeric (6-4) thymine photoproducts (6-4 PP) ...
Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser

Rodriguez-Alzueta, Ofelia; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Elsevier, 2019-07-05)

[EN] 2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting ...
Un enfoque de biología de sistemas para integrar la investigación sobre los mecanismos moleculares, celulares y tisulares del daño del ADN para mejorar la predicción del riesgo de cáncer.

Martínez Santa, Marta (Universitat Politècnica de València, 2021-01-19)

[ES] Existe un reconocimiento creciente de que el cáncer como enfermedad es el resultado de un fallo sistémico en el cual muchas células, además de aquellas con genomas oncogénicos, determinan la frecuencia de cáncer. Se ...