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Browsing by Subject "Metabolomics"

Now showing items 1-15 of 15

A Non-targeted Metabolomics Approach Unravels the VOCs Associated with the Tomato Immune Response against Pseudomonas syringae

López-Gresa, María Pilar; Lisón, Purificación; Campos Beneyto, Laura; Rodrigo Bravo, Ismael; Rambla Nebot, Jose Luis; Granell Richart, Antonio; Conejero Tomás, Vicente; Belles Albert, José Mª (Frontiers Media SA, 2017)

[EN] Volatile organic compounds (VOCs) emitted by plants are secondary metabolites that mediate the plant interaction with pathogens and herbivores. These compounds may perform direct defensive functions, i. e., acting as ...
Análisis bioinformático de los datos obtenidos en un análisis metabolómico no dirigido por espectrometría de masas mediante open-source software: MZmine2 y XCMS

Díaz Guillem, Carmen (2019-09-02)

[ES] Tecnologías ómicas como la metabolómica, cuyo objetivo es el análisis completo de los metabolitos presentes en una muestra biológica, han experimentado un vertiginoso desarrollo durante la última década, y ello ha ...
Análisis integrado del metaboloma y del proteoma de plantas de tomate infectadas con Pseudomonas syringae.

Gutiérrez Botella, Jesús (2018-10-08)

[ES] Pseudomonas syringae es una bacteria causante de muchas enfermedades en el reino vegetal. Este patógeno tiene un amplio espectro de huéspedes y sus síntomas se manifiestan en las hojas, con unas manchas acuosas que ...
Caracterización del perfil metabolómico asociado a la metástasis ganglionar en pacientes con melanoma mediante 1H-RMN.

Martínez Fernández de Córdova, Paula (2018-09-18)

[ES] Entre las enfermedades oncológicas, que actualmente constituyen la principal causa de muerte en el mundo, el cáncer de piel conforma el grupo más frecuente. En particular el melanoma destaca por su potencial ...
Cartografiado de QTL y genes candidatos asociados a metabolitos determinantes de la calidad de fruto en melocotón

Sánchez, Gerardo (2013-12-16)

Tradicionalmente los programas de mejora del melocotón (Prunus persica (L.) Batsch) se centraron fundamentalmente en la obtención de genotipos elite de alta productividad, resistentes a plagas y patógenos, adaptados a ...
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

Quintás, Guillermo; Portillo Poblador, Nuria; García Cañaveras, Juan Carlos; Castell, José Vicente; Ferrer, Alberto; Lahoz, Agustín (Springer Verlag (Germany), 2012-02)

An MS-based metabolomics strategy including variable selection and PLSDA analysis has been assessed as a tool to discriminate between non-steatotic and steatotic human liver profiles. Different chemometric approaches for ...
Comparativa de perfiles metabólicos asociados a la hiperglucemia y su tratamiento en ratón

Cardona Ferrer, Edgar Enrique (2018-10-04)

[ES] Para el estudio de las alteraciones producidas por la hiperglucemia, relacionadas con la diabetes mellitus, y en concreto la retinopatía diabética, se realiza un estudio comparativo de los perfiles metabólicos de las ...
Detection of prostate cancer using a voltammetric electronic tongue

Pascual, Lluís; Campos Sánchez, Inmaculada; Vivancos, José-Luis; Quintás, Guillermo; Loras Monfort, Alba; Martínez-Bisbal, M.Carmen; Martínez-Máñez, Ramón; Boronat-Tormo, Francisco; Ruiz Cerda, Jose Luis (Royal Society of Chemistry, 2016)

[EN] A simple method based on the multivariate analysis of data from urine using an electronic voltammetric tongue is used to detect patients with prostate cancer. A sensitivity of 91% and a specificity of 73% were obtained ...
Estudio del perfil metabólico de órganos de ratón por resonancia magnética nuclear e identificación de biomarcadores

Antón García, Pablo Antonio (2015-09-04)

[ES] Los modelos animales, especialmente ratón y rata, son instrumentos valiosos como indicadores predictivos de actividad clínica. Los perfiles metabólicos de biofluidos, tejidos y órganos de estos modelos pueden estar ...
Evaluation of the effect of chance correlations on variable selection using Partial Least Squares -Discriminant Analysis

Kuligowski, Julia; Pérez Guaita, David; Escobar, Javier; Guardia, Miguel de la; Vento, Máximo; Ferrer Riquelme, Alberto José; Quintás, Guillermo (Elsevier, 2013-11-15)

Variable subset selection is often mandatory in high throughput metabolomics and proteomics. However, depending on the variable to sample ratio there is a significant susceptibility of variable selection towards chance ...
Evaluation of unintended effects in the composition of tomatoes expressing a human immunoglobulin A against Rotavirus

Juárez Ortega, Paloma; Fernández Del Carmen, María Asunción; Rambla Nebot, Jose Luis; Presa Castro, Silvia; Mico, Amparo; Granell Richart, Antonio; Orzáez Calatayud, Diego Vicente (American Chemical Society, 2014-08-13)

The production of neutralizing immunoglobulin A (IgA) in edible fruits as a means of oral passive immunization is a promising strategy for the inexpensive treatment of mucosal diseases. This approach is based on the ...
GENES AND GENOMIC REGIONS RELATED TO THE PRODUCTION OF VOLATILE COMPOUNDS IN THE TOMATO FRUIT

Rambla Nebot, Jose Luis (2017-01-15)

[EN] Fruits both produce and emit volatile chemical compounds. These are short-chained low polarity molecules involved in many processes, and they are responsible of our perception of fruit aroma and of most of their ...
Integration of multi-omics data to describe link between developmental exposure to pesticides and impaired neurodevelopment

Bernabeu Gómez, Elena (2016-07-28)

[EN] In recent years the omics disciplines have made their way across a wider spectrum of research groups, thus leading to the generation of multi-omics data sets in a great number of studies. While traditional omics ...
Production of recombinant Immunoglobulin A in plants for passive immunotherapy.

Juárez Ortega, Paloma (2014-04-14)

Mucosal passive immunization is the transfer of active antibodies from one organism to the mucosal surfaces of another organism for preventing or treating infectious diseases. Mucosal passive immunization has a ...
Towards the potential use of (1)H NMR spectroscopy in urine samples for prostate cancer detection.

Zaragozá Torres, Patricia; Ruiz Cerda, Jose Luis; Quintás, Guillermo; Gil Grau, Salvador; Costero Nieto, Ana María; León, Zacarías; Vivancos, José-Luis; Martínez Mañez, Ramón (Royal Society of Chemistry, 2014-08-21)

A simple method based in multivariate analysis of 1H NMR spectra profiles of urine samples can be used to detect patients with prostate cancer.