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Browsing by Author "Trénor Gomis, Beatriz Ana"

Now showing items 1-20 of 91

A Multiscale in Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation. A Translational Study to Guide Ablation Therapy

Sánchez Arciniegas, Jorge Patricio (Universitat Politècnica de València, 2021-07-26)

[ES] La fibrilación auricular es la arritmia cardíaca más común. Durante la fibrilación auricular, el sustrato auricular sufre una serie de cambios o remodelados a nivel eléctrico y estructural. La remodelación eléctrica ...
Analysis of the response of human iPSC-derived cardiomyocyte tissue to I CaL block. A combined in vitro and in silico approach

Dasí, Albert; Hernández-Romero, Ismael; Gómez, Juan F.; Climent, Andreu M.; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana (Elsevier, 2021-10)

[EN] The high incidence of cardiac arrythmias underlines the need for the assessment of pharmacological therapies. In this field of drug efficacy, as in the field of drug safety highlighted by the Comprehensive in Vitro ...
Analysis of vulnerability to reentry in acute myocardial ischemia using a realistic human heart model

Carpio, Edison F.; Gómez, Juan F.; Rodríguez-Matas, José F.; Trenor Gomis, Beatriz Ana; Ferrero De Loma-Osorio, José María (Elsevier, 2022-02)

[EN] Electrophysiological alterations of the myocardium caused by acute ischemia constitute a pro-arrhythmic substrate for the generation of potentially lethal arrhythmias. Experimental evidence has shown that the ...
Análisis comparativo del efecto farmacológico en células ventriculares sanas y con insuficiencia cardíaca mediante métodos de modelado y simulación

Llopis Lorente, Jordi (Universitat Politècnica de València, 2018-10-10)

[ES] Uno de los posibles efectos secundarios de un fármaco es la generación de Torsade de Pointes (TdP), una taquicardia ventricular potencialmente letal, responsable de la retirada de muchos fármacos del mercado. Por ello, ...
Análisis del uso del póster científico y de la revisión por pares como herramienta desarrollo de la competencia comunicación efectiva en estudiantes de grado en ingeniería

Prats Boluda, Gema; Ye Lin, Yiyao; Trénor Gomis, Beatriz Ana (Editorial Universitat Politècnica de València, 2016-07-19)

[EN] Today’s society requires graduates who present a wide range of cross skills in addition to master the specific skills of their grade, as in the case of effective communication skill. In this paper the use of ...
Análisis mediante simulación de la insuficiencia cardíaca en tejido ventricular humano

Gómez García, Juan Francisco (Universitat Politècnica de València, 2013-02-19)

[ES] Este trabajo se centra en el desarrollo de un modelo de potencial de acción ventricular humano propio de células afectadas de insuficiencia cardíaca, para analizar la aparición de posibles efectos arritmogénicos en ...
APD, QT interval and Tx Values

Saiz Rodríguez, Francisco Javier; Sanz i Carreras, Ferran; Pastor Maeso, Manuel; Trénor Gomis, Beatriz Ana; Gomis-Tena Dolz, Julio; Cano García, Jordi; Romero Pérez, Lucia (Universitat Politècnica de València, 2017-10-31)

This repository contains four Excel 2017 files named “APD.xlsx”, “QT.xlsx”, “Tx_APD.xlsx” and “Tx_QT.xlsx”. APD.xlsx and Tx_APD.xlsx files contain three sheets (called “Epi”, “Mid” and “Endo”), whereas the rest contain ...
Aplicación de la Clase Inversa en la Enseñanza de la Electrónica Analógica en un Grupo de Alto Rendimiento Académico

Trénor Gomis, Beatriz Ana; Prats Boluda, Gema; Ye Lin, Yiyao (Editorial Universitat Politècnica de València, 2017-07-18)

[EN] The need of increasing the participation of the student in the teaching and learning process at University has led to the concept of flip teaching. This methodology is characterized by the fact that the student works ...
Application of Machine Learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia

Rodriguez-Belenguer, Pablo; Kopanska, Karolina; Llopis-Lorente, Jordi; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Pastor, Manuel (Elsevier, 2023-03)

[EN] Background and Objective In silico prediction of drug-induced ventricular arrhythmia often requires computationally intensive simulations, making its application tedious and non-interactive. This inconvenience can ...
Application of Machine Learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia

Rodríguez-Belenguer, Pablo; Kopańska, Karolina; Llopis Lorente, Jordi; Trénor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Pastor, Manuel (Universitat Politècnica de València, 2022-06-03)

In cardiotoxicity studies it is common to pre-compute the values of different biomarkers (my equation or TX) for a range of ion channel blockades. Since every simulation requires costly computations, to complete the matrix ...
Aprendizaje de competencias específicas en asignaturas técnicas con elevado número de alumnos: Análisis de la asignatura Instrumentación y Control Industrial

Prats-Boluda, Gema; Garcia-Casado, Javier; Ye Lin, Yiyao; Trénor Gomis, Beatriz; Guijarro-Estellés, Enrique; Martínez-de-Juan, José Luis (Editorial Universitat Politècnica de València, 2023-04-04)

[ES] La evaluación de las competencias específicas en titulaciones técnicas suele ser sumativa y articulada en pruebas escritas y memorias a entregar mayoritariamente al finalizar el periodo docente. Los alumnos concentran ...
Arrhythmia Mechanism and Scaling Effect on the Spectral Properties of Electroanatomical Maps with Manifold Harmonics

Sanroman-Junquera, Margarita; Mora-Jimenez, Inmaculada; Garcia-Alberola, Arcadio; Caamano, Antonio J.; Trénor Gomis, Beatriz Ana; Rojo-Alvarez, Jose L. (Institute of Electrical and Electronics Engineers, 2018)

[EN] Introduction: Spatial and temporal processing of intracardiac electrograms provides relevant information to support the arrhythmia ablation during electrophysio-logical studies. Current cardiac navigation systems (CNS) ...
Blocking L-Type Calcium Current Reduces Vulnerability to Re-Entry in Human iPSC-Derived Cardiomyocytes Tissue

Dasi, Albert; Climent, Andreu M.; Martínez, Laura; Gómez, Juan F.; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana (IEEE, 2019-09-11)

[EN] Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have proven to be crucial in pharmacological assessment. Nevertheless, their response to drugs when coupled forming a tissue is not fully understood. ...
Ca2+ alternans in human heart failure and its modulation by fibroblasts

Mora Fenoll, María Teresa; Gómez García, Juan Francisco; Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2019)

The functional coupling between myocytes and fibroblasts can alter the electrophysiology of myocytes, which is a major problem in heart failure. The code provides the mathematical model to simulate this interaction, and ...
Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

Mora-Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Gómez García, Juan Francisco; Sobie, Eric A.; Trenor Gomis, Beatriz Ana (Frontiers Media SA, 2018-08-23)

[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...
Captación, acondicionamiento y digitalización de señales electrooculográficas en código Morse

Bozzo Parada, Emilio Ignacio (Universitat Politècnica de València, 2021-10-19)

[ES] Se propone la realización de un TFG que consistente en la captación, acondicionamiento y preamplificación de una señal electrooculográfica que reproduzca el código morse. Mediante el parpadeo de ojos, un paciente ...
Caracterización eléctrica de transistores electroquímicos utilizados para electrofisiología in vitro

Scholaert, Corentin Daniel Patrick (Universitat Politècnica de València, 2021-10-18)

[ES] El proyecto ERC-IONOS propone cambiar el paradigma de interfaz cerebro-máquina mediante el desarrollo de nuevas tecnologías diseñadas para interactuar íntimamente con las células biológicas, inspirándose en gran medida ...
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R. (Frontiers Media, 2013-10)

Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and ...
Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour

Trenor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Noble, Denis; Giles, Wayne (Blackwell Publishing, 2017-11-01)

[EN] In healthy mammalian hearts the action potential (AP) waveform initiates and modulates each contraction, or heartbeat. As a result, AP height and duration are key physiological variables. In addition, rate-dependent ...
Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes

K Cardona; Trénor Gomis, Beatriz Ana; W Giles (Public Library of Science, 2016-11-22)

The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial and ventricular rhythm disturbances in the human heart. However, the cellular and molecular mechanisms that underlie these ...