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Browsing by Author "Andreu Ros, María Inmaculada"

Now showing items 1-20 of 33

"Snorkelling" vs. "diving" in mixed micelles probed by means of a molecular bathymeter

Rodríguez Muñiz, Gemma María; Gomez Mendoza, Miguel; Nuin Pla, Neus Edurne; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2017)

[EN] A photoactive bathymeter based on a carboxylic acid moiety covalently linked to a signalling methoxynaphthalene (MNP) fluorophore has been designed to prove the concept of "snorkelling" vs. "diving" in mixed micelles ...
A New Pathway for Protein Haptenation by beta-Lactams

Pérez-Ruiz, Raúl; Lence, Emilio; Andreu Ros, María Inmaculada; Limones Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-10-09)

[EN] The covalent binding of beta-lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human ...
Allergic Reactions to Metamizole: Immediate and Delayed Responses

Blanca-López, Natalia; Pérez-Sanchez, Natalia; Agúndez, Jose A.G.; García-Martín, Elena; Torres, Maria José; Cornejo-Garcia, José Antonio; Perkins, James R.; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada; Mayorga, Cristobalina; Canto, María Gabriela; Blanca, Miguel; Doña, Inmaculada (S. Karger AG, 2016)

[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to ...
Assessment of drug entrapment within liposomes using photophysical probes

Oliverio, Filomena; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Ragno, Gaetano; Miranda Alonso, Miguel Ángel (Elsevier, 2014-10)

The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer ...
Biradical vs singlet oxygen photogeneration in suprofen cholesterol systems

Palumbo, Fabrizio; Bosca Mayans, Francisco; Morera Bertomeu, Isabel María; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (Beilstein-Institut, 2016-06-14)

Cholesterol (Ch) is an important lipidic building block and a target for oxidative degradation, which can be induced via free radicals or singlet oxygen (1O2). Suprofen (SP) is a nonsteroidal anti-inflammatory drug that ...
Configuration-dependent photoinduced electron transfer in diastereomeric naphthalene-amino-naphthalene triads

Nuin Pla, Neus Edurne; Sastre Navarro, German Ignacio; Pischel, Uwe; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2015)

[EN] Novel diastereomeric triads containing two naphthalene chromophores have been designed in which an electron-donating amine moiety is covalently integrated into the connecting bridge. Photophysical studies (steady-state ...
Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-05-16)

A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Enhanced photosafety of cinacalcet upon complexation with serum albumin

Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-02-10)

Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Estudio de las reacciones radicalarias del colesterol en diadas modelo

Palumbo, Fabrizio (Universitat Politècnica de València, 2014-11-28)

[EN] Cholesterol (Ch) is one of the most important building blocks of cell membranes. It is also one of the main targets for oxidation via Type I hydrogen abstraction (HA), which leads to a variety of physiological ...
Evaluación de la fotoestabilidad y la foto(geno)toxicidad in vitro del fármaco simeprevir

Moreno Muñoz, Alejandro (Universitat Politècnica de València, 2018-09-18)

[ES] El fármaco simeprevir (SIM) se utiliza en el tratamiento de la infección crónica por el virus de la hepatitis C (VHC), principalmente el genotipo 1, formando parte de una terapia antiviral combinada con otros fármacos. ...
Evaluación de un posible mecanismo para la fotoalergia causada por el filtro solar octocrileno

Rivera Rincón, Mary Julieth (Universitat Politècnica de València, 2015-09-18)
Examples for biological reactivity involving free radicals followed by CIDNP

Andreu Ros, María Inmaculada; Neshchadin, Dmytro; Batchelor, Stephen N.; Miranda Alonso, Miguel Ángel; Gescheidt, Georg (Taylor & Francis, 2013-10-01)

It is shown how chemically induced dynamic nuclear polarisation (CIDNP) spectroscopy is able to efficiently complement electron paramagnetic resonance (EPR), when molecular transformations of free radical pairs are ...
Fluoroquinolone photodegradation influences specific basophil activation

Mayorga, Cristobalina; Andreu Ros, María Inmaculada; Aranda, Ana; Doña, Inmaculada; Montañez, M. Isabel; Blanca-López, Natalia; Ariza, Adriana; Nuin Plá, Neus Edurne; Blanca, Miguel; Miranda Alonso, Miguel Ángel; Torres, Mª José (Karger, 2013)

Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has ...
Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives

Blanca-López, Natalia; Pérez-Alzate, D.; Andreu Ros, María Inmaculada; Doña, Inmaculada; Agundez, Javier A.; García-Martín, Elena; Salas, M.; Miranda Alonso, Miguel Ángel; Torres, M. J.; Cornejo-Garcia, J.A.; Blanca, M.; Canto, G. (Wiley, 2016-07)

[EN] Background: Although ibuprofen and other arylpropionic acid derivatives (APs) are the most common medicines involved in hypersensitivity drug reactions (HDRs) to NSAIDs, no patient series studies have been performed ...
In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones

Aranda, A.; Mayorga, C.; Ariza, A.; Doña, I.; Rosado, A.; Blanca-López, N.; Andreu Ros, María Inmaculada; Torres, M.J. (Wiley-Blackwell, 2011)

Background: Hypersensitivity IgE-mediated reactions to quinolones are not easy to diagnose, with skin testing inducing false positive results. The aim of the study was to evaluate the in vitro-specific IgE response in ...
Influence of drug encapsulation within mixed micelles on the excited state dynamics and accessibility to ionic quenchers

Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Marín García, Mª Luisa; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-08-15)

Photophysical techniques, specifically time-resolved fluorescence and laser flash photolysis, have proven to be noninvasive, straightforward, and valuable tools to demonstrate how drug encapsulation into biomimetic mixed ...
Mechanistic Studies on the Photoallergy Mediated by Fenofibric Acid: Photoreactivity with Serum Albumins

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Monje-López, Vicente Tomás; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2016-01)

[EN] The photoreactivity of fenofibric acid (FA) in the presence of human and bovine serum albumins (HSA and BSA, respectively) has been investigated by steady-state irradiation, fluorescence, and laser flash photolysis ...
Multiple nonsteroidal anti-inflammatory drug hypersensitivity without hypersensitivity to aspirin

Perez-Sanchez, Natalia; Bogas, Gador; Cornejo-Garcia, José Antonio; Andreu Ros, María Inmaculada; Doña, Inmaculada; Perez-Alzate, Diana; Blanca-López, Natalia (Elsevier, 2016)

Subjects developing anaphylaxis or urticaria/angioedema after chemically unrelated nonsteroidal antiinflammatory drug intake should not be classified as cross-hypersensitive unless they do not tolerate acetyl salicylic ...
Naphtalene triplet excited state as a probe for the assessment of drug distribution in binary protein systems

Pérez Ruiz, Raúl; Alonso Ruiz, Rafael; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-04-21)

[EN] Three drugs containing the naphthalene (NP) chromophore, namely, naproxen (NPX), propranolol (PPN), and cinacalcet (CIN), but with different affinities toward serum albumins (SAs) and alpha-1-acid glycoproteins (AAGs) ...