González, Rubén; Butkovic, Anamarija; ELENA FITO, SANTIAGO FCO(Oxford University Press, 2019-07)
[EN] Predicting viral emergence is difficult due to the stochastic nature of the underlying processes and the many factors that govern pathogen evolution. Environmental factors affecting the host, the pathogen and the ...
Tromas, Nicolas; Zwart, Mark Peter; Forment Millet, José Javier; Elena Fito, Santiago Fco(Oxford University Press, 2014)
[EN] Nonretroviral integrated RNA viruses (NIRVs) are genes of nonretroviral RNA viruses found in the genomes of many eukaryotic organisms. NIRVs are thought to sometimes confer virus resistance, meaning that they could ...
Valverde, Sergi; ELENA FITO, SANTIAGO FCO; Solé, Ricard(Oxford University Press, 2017-08-02)
[EN] Ecological networks, both displaying mutualistic or antagonistic interactions, seem to share common structural traits: the presence of nestedness and modularity. A variety of model approaches and hypothesis have been ...
Rodrigo, Guillermo; Elena Fito, Santiago Fco(Public Library of Science, 2011-02-14)
Signaling pathways are interconnected to regulatory circuits for sensing the environment and expressing the appropriate genetic profile. In particular, gradients of diffusing molecules (morphogens) determine cell fate at ...
Lafforgue, Guillaume; Martínez García, Fernando; Sardanyes Cayuela, Jose; De la Iglesia Jordán, Francisca; Niu, Qi-Wen; Lin, Shih-Shun; Sole, Ricard V.; Chua, Nam-Hai; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(American Society for Microbiology, 2011)
A biotechnological application of artificial microRNAs (amiRs) is the generation of plants that are resistant to virus infection. This resistance has proven to be highly effective and sequence specific. However, before ...
Cuevas, Jose M.; Willemsen, A; Hillung, Julia; Zwart, Mark Peter; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2015-05)
[EN] Populations of plant RNA viruses are highly polymorphic in infected plants, which may allow rapid within-host evolution. To understand tobacco etch potyvirus (TEV) evolution, longitudinal samples from experimentally ...
Zwart, Mark Peter; Elena Fito, Santiago Fco(American Phytopathological Society, 2015-01)
[EN] The independent action hypothesis is a simple model of pathogen infection that can make many useful predictions on infection kinetics and, therefore, a number of different tests of independent action have been developed. ...
de Visser, J. Arjan G. M.; Cooper, Tim F.; Elena Fito, Santiago Fco(Royal Society, The, 2011-12-22)
[EN] Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions-called epistasis-have been the topic of a vast research effort. Systems and developmental biologists study ...
Macia, Javier; Sole, Ricard V.; Elena Fito, Santiago Fco(Wiley, 2012-02)
[EN] Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative ...
Zhang, Xiaoan; Ryu, Soo Hyung; Xu, Yanjuan; Elbaz, Tamerl; Zekri, Abdel-Rahman N.; Abdelaziz, Ashraf Omar; Abdel-Hamid, Mohamed; Thiers, Valerie; Elena Fito, Santiago Fco; Fan, Xiaofeng; Di Bisceglie, Adrian M.(Elsevier, 2011-12)
[EN] Background: Hepatitis C virus (HCV) infection is a well-documented etiological factor for hepatocellular carcinoma (HCC). As HCV shows remarkable genetic diversity, an interesting and important issue is whether such ...
Elena Fito, Santiago Fco; Bedhomme, Stephanie; Carrasco, Purificación; Cuevas, Jose M.; De la Iglesia Jordán, Francisca; Lafforgue, Guillaume; Lalic, Jasna; Prosper Pontones, Angels; Tromas, Nicolas; Zwart, Mark Peter(American Phytopathological Society, 2011-03)
[EN] Over the years, agriculture across the world has been compromised by a succession of devastating epidemics caused by new viruses that spilled over from reservoir species or by new variants of classic viruses that ...
Elena Fito, Santiago Fco; Bernet, Guillermo P.; Carrasco Jiménez, José Luis(Elsevier, 2014-10)
[EN] Mixed virus infections in plants are common in nature. The outcome of such virus–virus interactions ranges from cooperation and coexistence (synergism) to mutual exclusion (antagonism). A priori, the outcome of mixed ...
Hillung, Julia; García-García, Francisco; DOPAZO, JOAQUÍN; Cuevas Torrijos, Jose Manuel; Elena Fito, Santiago Fco(Nature Publishing Group, 2016-04-26)
[EN] Models of plant-virus interaction assume that the ability of a virus to infect a host genotype depends on the matching between virulence and resistance genes. Recently, we evolved tobacco etch potyvirus (TEV) lineages ...
Kutnjak, D.; Elena Fito, Santiago Fco.; Ravnikar, M.(American Society for Microbiology, 2017-08)
[EN] RNA viruses are one of the fastest evolving biological entities. Within their hosts, they exist as genetically diverse populations (i.e., viral mutant swarms), which are sculpted by different evolutionary mechanisms, ...
Bosque, Gabriel; Folch Fortuny, Abel; Picó Marco, Jesús Andrés; Ferrer, Alberto; Elena Fito, Santiago Fco(BioMed Central, 2014-11-20)
Background: One of the central interests of Virology is the identification of host factors that contribute to virus infection. Despite tremendous efforts, the list of factors identified remains limited. With omics techniques, ...
Elena Fito, Santiago Fco; Rodrigo Tarrega, Guillermo(Elsevier, 2012-12)
[EN] The application in recent years of network theory methods to the study of host-virus interactions is providing a new perspective to the way viruses manipulate the host to promote their own replication. An integrated ...
Hillung, Julia; Cuevas Torrijos, Jose Manuel; Elena Fito, Santiago Fco(Frontiers Media, 2012-06)
The use of high-throughput transcript profiling techniques has opened the possibility of
identifying, in a single experiment, multiple host mRNAs whose levels of accumulation are
altered in response to virus infection. ...
Hasiow-Jaroszewska, B; Czerwoniec, A; Pospieszny, H; Elena Fito, Santiago Fco(BioMed Central, 2011-06-24)
[EN] Background: Pepino mosaic virus (PepMV) is considered one of the most dangerous pathogens infecting tomatoes worldwide. The virus is highly diverse and four distinct genotypes, as well as inter-strain recombinants, ...
Martinez Garcia, Fernando; Lafforgue, Guillaume; Morelli, M.; González-Candelas, F.; CHUA, N.H.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2012-11)
[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...
Sardanyes Cayuela, Jose; Simó, Carles; Martínez, Regina; Solé, Ricard V.; Elena Fito, Santiago Fco(Nature Publishing Group, 2014-04-09)
[EN] The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a ...