Llaneras Estrada, Francisco(Universitat Politècnica de València, 2011-03-23)
This thesis is devoted to the study and application of constraint-based metabolic models. The objective was to find simple ways to handle the difficulties that arise in practice due to uncertainty (knowledge is incomplete, ...
Dehesa Valencia, Julio César(Universitat Politècnica de València, 2013-03-27)
Esta tesis se enfoca principalmente en el control robusto de sistemas no lineales planos. El objetivo principal es determinar una familia de controladores robustos con la finalidad de asegurar el cumplimiento de un conjunto ...
Vignoni, Alejandro(Editorial Universitat Politècnica de València, 2014-05-26)
The present thesis employs ideas of set invariance and sliding modes
in order to deal with different relevant problems control of nonlinear
systems. Initially, it reviews the techniques of set invariance as well as
the ...
Folch-Fortuny, Abel; Tortajada Serra, Marta; Prats-Montalbán, José Manuel; Llaneras Estrada, Francisco; Picó Marco, Jesús Andrés; Ferrer Riquelme, Alberto José(Elsevier, 2015-03-15)
[EN] With the aim of understanding the flux distributions across a metabolic network, i.e. within living cells, Principal Component Analysis (PCA) has been proposed to obtain a set of orthogonal components (pathways) ...
[EN] Within the emergent field of Systems Biology, mathematical models obtained from physical chemical laws (the so-called first principles-based models) of microbial systems are employed to discern the principles that ...
Picó Marco, Jesús Andrés; Vignoni, Alejandro; Picó i Marco, Enric; Boada Acosta, Yadira Fernanda(Universitat Politècnica de València, 2015-07-10)
[EN] In the last decade we have witnessed a growing application of engineering techniques to biology. Areas such as Systems Biology or, more recently, Synthetic Biology, get more and more attention from the engineers. ...
González Cebrián, Alba(Universitat Politècnica de València, 2016-07-12)
[ES] En el presente trabajo se ha realizado la caracterización y clasificación de trastornos del
sueño a partir de los EEGs registrados en Polisomnografías. Mediante la Transformada Wavelet
Discreta, se han obtenido ...
Boada-Acosta, Yadira Fernanda; Santos-Navarro, Fernando Nóbel; Picó, Jesús; Vignoni, Alejandro(Frontiers Media SA, 2022-03-29)
[EN] Achieving optimal production in microbial cell factories, robustness against changing intracellular and environmental perturbations requires the dynamic feedback regulation of the pathway of interest. Here, we consider ...
Camacho, José; Picó Marco, Jesús Andrés(Universitat Politècnica de València, 2010-01-07)
[EN] Statistical methods, like Principal Components Analysis (PCA), have been widely used for batch process monitoring. Nonetheless, these methods are based on the adjustment of a linear model to the process data. Hence, ...
Background: Model based design plays a fundamental role in synthetic biology. Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key ...
Santos Navarro, Fernando Nóbel(Universitat Politècnica de València, 2022-06-20)
[ES] Esta Tesis ha sido dedicada al modelado multiescala considerando al anfitrión celular para el análisis y ajuste de circuitos genéticos sintéticos para bioproducción.
Los objetivos principales fueron:
1. El desarrollo ...
Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús(Institute of Electrical and Electronics Engineers, 2020-01)
[EN] Kinetic (i.e., dynamic) semimechanistic models based on the first principles are particularly important in systems and synthetic biology since they can explain and predict the functional behavior that emerges from the ...
Bosque Chacón, Gabriel(Universitat Politècnica de València, 2017-03-27)
This thesis is dedicated to the study and comprehension of biological networks at the molecular level. The objectives were to analyse their topology, integrate it in a genotype-phenotype analysis, develop richer mathematical ...
Vila Molina, María(Universitat Politècnica de València, 2023-10-20)
[ES] El cerebro desempeña un papel central en la tarea de controlar y regular las diversas funciones del organismo. Es un órgano complejo compuesto por regiones especializadas que están interconectadas y son responsables ...
[EN] This paper deals with the regulation of the biomass specific growth rate, which is an important goal in many fed-batch fermentation processes. The proposed control system is based on the minimal model paradigm, requiring ...
Blas González, Irene(Universitat Politècnica de València, 2022-05-25)
[ES] El proyecto se basa en el estudio del problema de la generación de trayectoria y control lateral sobre la misma, considerando un modelo de bicicleta para un vehículo autónomo. Este modelo es válido para bajas velocidades, ...
[EN] Synthetic biology is reaching the situation where tuning devices by hand is no longer possible due to the complexity of the biological circuits being designed. Thus, mathematical models need to be used in order, not ...
De Battista, Hernán; Picó-Marco, Enric; Santos-Navarro, Fernando Nóbel; Picó, Jesús(Institute of Electrical and Electronics Engineers, 2019-07-04)
[EN] Turbidostats are a class of bioreactors gaining interest due to the recent availability of microscale and small-scale devices for characterization and scalingup of the biotechnological systems relevant in the biotech ...
[EN] Synthetic biology exploits the of mathematical modeling of synthetic circuits both to predict the behavior of the designed synthetic devices, and to help on the selection of their biological coin portents. The increasing ...
Background: Metabolic Flux Analysis (MFA) is a methodology that has been successfully applied to estimate
metabolic fluxes in living cells. However, traditional frameworks based on this approach have some limitations,
...