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Browsing by Author "Jiménez Molero, María Consuelo"

Now showing items 1-20 of 69

A combined photophysical and computational study on the binding of mycophenolate mofetil and its major metabolite to transport proteins

Vendrell-Criado, Victoria; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (Elsevier, 2018-06-15)

[EN] Binding of the inmunodrepresive agent mycophenolate mofetil (MMP) and its pharmacologically active metabolite mycophenolic acid (MPA) to human serum albumin (HSA) and ¿1-acid glycoprotein (HAAG) has been investigated ...
A joint experimental/theoretical study of the ultrafast excited state deactivation of deoxyadenosine and 9-methyladenine in water and acetonitrile

Gustavsson, Thomas; Sarkar, Nilmoni; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Markovitsi, Dimitra; Improta, Roberto (Royal Society of Chemistry, 2013)

The excited states of deoxyadenosine (dA) and 9-methyladenine (9Me-Ade) were studied in water and acetonitrile by a combination of steady-state and time-resolved spectroscopy and quantum chemical calculations. Femtosecond ...
A New Pathway for Protein Haptenation by beta-Lactams

Pérez-Ruiz, Raúl; Lence, Emilio; Andreu Ros, María Inmaculada; Limones Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-10-09)

[EN] The covalent binding of beta-lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human ...
Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence

Pais, Vania F.; Neumann, T.; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Ros, Abel; Pischel, Uwe (Beilstein-Institut, 2019-11-04)

[EN] Four new dyes that derive from borylated arylisoquinolines were prepared, containing a third aryl residue (naphthyl, 4-methoxynaphthyl, pyrenyl or anthryl) that is linked via an additional stereogenic axis. The triaryl ...
Bypassing the energy barrier of homolytic photodehalogenation in chloroaromatics through self-quenching

Limones Herrero, Daniel; Pérez Ruiz, Raul; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013)

Reductive photodehalogenation of chloroaromatics is assumed to proceed from the triplet excited state, although its energy is often insufficient to promote a clean homolytic C¿Cl cleavage. A clear-cut experimental proof ...
Characterization of the lowest singlet and triplet states of S-Flurbiprofen

Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Tormos Faus, Rosa Esperanza; Vayá Pérez, Ignacio (The Royal Society of Chemistry, 2004)

[EN] The photophysical properties of S-flurbiprofen [S-2-fluoro-alpha-methyl-4-biphenylacetic acid], a nonsteroidal anti-inflammatory drug, have been examined using steady-state and time-resolved spectroscopic techniques. ...
Cycloreversion of beta-lactams via photoinduced electron transfer

Pérez Ruiz, Raul; Sáez Cases, José Antonio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2014-11-14)

The radical anions of beta-lactams, photogenerated in the presence of DABCO as an electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to olefins. The ...
Determination of enantiomeric compositions by transient absorption spectroscopy using proteins as chiral selectors

Vayá Pérez, Ignacio; Bueno Alejo, Carlos Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2008)
Diastereodifferentiation of novel naphthalene dyads by fluorescence quenching and excimer formation

Abad Fuentes, Sergio; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Pischel ., Uwe; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2006)

[EN] Four new bichromophoric naphthalene dyads in form of diastereomeric pairs are synthesized and photophysically characterized. For a closely related group of compounds (NAP-NAP MNAP-NAP, MNAP-MNAP), systematic variation ...
Diseño de nanopartículas de oro funcionalizadas con AINEs y proteínas para su uso en biomedicina

Tamarit Mayo, Lorena (Universitat Politècnica de València, 2018-10-11)

[ES] En este trabajo se han diseñado una serie de nanopartículas de oro (AuNPs) esféricas funcionalizadas con fármacos (antiinflamatorios no esteroideos, AINEs) con la finalidad de realizar un estudio fotofísico completo ...
Diseño de nanorods de oro con fármacos fotoactivos para estudios de citotoxicidad celular

Palomares Ferrando, Adrià (Universitat Politècnica de València, 2021-10-06)

[ES] Este proyecto se ha centrado en el diseño y estudio de las propiedades de nanorods de oro para su posible aplicación en terapia fototérmica (PTT), para el tratamiento de ciertos tipos de cánceres. La terapia fototérmica ...
Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-05-16)

A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Drug/protein interactions studied by time-resolved fluorescence spectroscopy

Gustavsson, Thomas; Markovitsi, Dimitra; Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (Society of Photo-optical Instrumentation Engineers (SPIE), 2014)

[EN] We report here on a recent time-resolved fluorescence study [1] of the interaction between flurbiprofen (FBP), a chiral non-steroidal anti-inflammatory drug, and human serum albumin (HSA), the main transport protein ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Enhanced photosafety of cinacalcet upon complexation with serum albumin

Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-02-10)

Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Especies transitorias en sistemas bioorgánicos modelo conteniendo cromóforos de tipo bifenilo, naftaleno o benzofenona

Bonancía Roca, Paula (Universitat Politècnica de València, 2013-03-07)

La espectroscopía de absorción transitoria ha resultado ser una herramienta útil para investigar la formación y desaparición de estados excitados singlete formados por aniquilación triplete-triplete, tras sensibilización. ...
Estados excitados del antiinflamatorio no esteroideo flurbiprofeno como sondas para la interacción con proteínas

Vayá Pérez, Ignacio (Universitat Politècnica de València, 2008-05-07)

Las proteínas son macromoléculas muy abundantes en los organismos vivos. En concreto, la importancia de las proteínas transportadoras (como albúmina sérica humana y bovina) radica en que actúan como vehículo para la ...
Estudio de la actividad fotocatalítica de colorantes de nueva generación

Hernandis Altur, Vicente (Universitat Politècnica de València, 2021-09-02)

[ES] Actualmente, la fotocatálisis empleando luz visible cómo fuente de energía está considerada como una de las áreas de investigación más punteras dentro de la síntesis orgánica. Por tanto, el objetivo principal de este ...
Estudio del comportamiento fotofísico y fotoquímico de la ezetimiba

Sanjuan Mira, Paola (Universitat Politècnica de València, 2014-10-02)

Proyecto confidencial (Riunet)
Estudio fotofísico de sistemas bicromofóricos conteniendo flurbiprofeno y tirosina

Rondón Sarmiento, Yameiri (Universitat Politècnica de València, 2016-01-13)