Vendrell-Criado, Victoria; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(Elsevier, 2018-06-15)
[EN] Binding of the inmunodrepresive agent mycophenolate mofetil (MMP) and its pharmacologically active metabolite mycophenolic acid (MPA) to human serum albumin (HSA) and ¿1-acid glycoprotein (HAAG) has been investigated ...
Gustavsson, Thomas; Sarkar, Nilmoni; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Markovitsi, Dimitra; Improta, Roberto(Royal Society of Chemistry, 2013)
The excited states of deoxyadenosine (dA) and 9-methyladenine (9Me-Ade) were studied in water and
acetonitrile by a combination of steady-state and time-resolved spectroscopy and quantum chemical
calculations. Femtosecond ...
Pérez-Ruiz, Raúl; Lence, Emilio; Andreu Ros, María Inmaculada; Limones Herrero, Daniel; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(John Wiley & Sons, 2017-10-09)
[EN] The covalent binding of beta-lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human ...
[EN] Four new dyes that derive from borylated arylisoquinolines were prepared, containing a third aryl residue (naphthyl, 4-methoxynaphthyl, pyrenyl or anthryl) that is linked via an additional stereogenic axis. The triaryl ...
Limones Herrero, Daniel; Pérez Ruiz, Raul; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013)
Reductive photodehalogenation of chloroaromatics is assumed to proceed from the triplet excited state, although its energy is often insufficient to promote a clean homolytic C¿Cl cleavage. A clear-cut experimental proof ...
Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Tormos Faus, Rosa Esperanza; Vayá Pérez, Ignacio(The Royal Society of Chemistry, 2004)
[EN] The photophysical properties of S-flurbiprofen [S-2-fluoro-alpha-methyl-4-biphenylacetic acid], a nonsteroidal anti-inflammatory drug, have been examined using steady-state and time-resolved spectroscopic techniques. ...
Pérez Ruiz, Raul; Sáez Cases, José Antonio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014-11-14)
The radical anions of beta-lactams, photogenerated in the presence of DABCO as an electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to olefins. The ...
Abad Fuentes, Sergio; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Pischel ., Uwe; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2006)
[EN] Four new bichromophoric naphthalene dyads in form of diastereomeric pairs are synthesized and photophysically characterized. For a closely related group of compounds (NAP-NAP MNAP-NAP, MNAP-MNAP), systematic variation ...
Tamarit Mayo, Lorena(Universitat Politècnica de València, 2018-10-11)
[ES] En este trabajo se han diseñado una serie de nanopartículas de oro (AuNPs) esféricas funcionalizadas con fármacos (antiinflamatorios no esteroideos, AINEs) con la finalidad de realizar un estudio fotofísico completo ...
Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-05-16)
A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Gustavsson, Thomas; Markovitsi, Dimitra; Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Society of Photo-optical Instrumentation Engineers (SPIE), 2014)
[EN] We report here on a recent time-resolved fluorescence study [1] of the interaction between flurbiprofen (FBP), a chiral non-steroidal anti-inflammatory drug, and human serum albumin (HSA), the main transport protein ...
Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada(Elsevier, 2016)
Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-02-10)
Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Bonancía Roca, Paula(Universitat Politècnica de València, 2013-03-07)
La espectroscopía de absorción transitoria ha resultado ser una
herramienta útil para investigar la formación y desaparición de estados
excitados singlete formados por aniquilación triplete-triplete, tras
sensibilización. ...
Vayá Pérez, Ignacio(Universitat Politècnica de València, 2008-05-07)
Las proteínas son macromoléculas muy abundantes en los organismos vivos. En concreto, la importancia de las proteínas transportadoras (como albúmina sérica humana y bovina) radica en que actúan como vehículo para la ...