Highly porous chitosan/hydroxyapatite composite
structures with different weight ratios (100/0; 90/10; 80/20;
70/30; 60/40; 50/50; 40/60) have been prepared by precipitation
method and freeze-gelation technique using ...
[EN] Definitive hematopoietic stem cells (HSCs) derive from specialized regions of the endothelium known as the hemogenic endothelium (HE) during embryonic developmental processes. This knowledge opens up new possibilities ...
Genetically modified Lactococcus lactis, non-pathogenic bacteria expressing the FNIII7-10 fibronectin
fragment as a protein membrane have been used to create a living biointerface between synthetic materials
and mammalian ...
Llopis Hernández, Virginia(Universitat Politècnica de València, 2017-11-03)
This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It ...
Alves, C. F. Almeida; Fialho, L.; Marques, S. M.; Pires, S.; Rico Tortosa, Patricia María; Palacio, C.; Carvalho, S.(Elsevier, 2021-05)
[EN] The formation of a porous oxide surface doped with osteoconductive elements, Ca, P and Mg, to enhance osseointegration, was achieved through micro arc oxidation. Micro arc oxidation parameters, such as electrolyte ...
Marques, S.M.; Rico Tortosa, Patricia María; Carvalho, I.; Gómez Ribelles, José Luís; Fialho, L.; Lanceros-Méndez, S.; Henriques, M.; Carvalho, S.(American Chemical Society, 2016-02-17)
In the sensors field, titanium based coatings are being used for the acquisition/application of electrical signals from/to piezoelectric materials. In this particular case, sensors are used to detect dynamic mechanical ...
[EN] In the present work the surface of Ti6Al4V alloy, widely used for the fabrication of implants, was modified by incorporating a novel biocompatible and antibacterial coating composed of multiple layers of hydroxyapatite ...
Trujillo Martínez, César(Universitat Politècnica de València, 2019-09-05)
[ES] Los avances recientes de la ingeniería tisular están explorando la liberación de factores de crecimiento, biomoléculas pequeñas e iones desde el biomaterial para conseguir diversos efectos terapéuticos tales como la ...
Llopis Hernández, Virginia(Universitat Politècnica de València, 2013-03-03)
[ES] La respuesta celular a los sustratos sintéticos puede ser controlada a través de los fenómenos que ocurren en la interfase célula-material. Uno de los fenómenos menos estudiados es el remodelado de las proteínas de ...
Mnatsakanyan Movsesyan, Hayk(Universitat Politècnica de València, 2019-07-03)
[ES] Los procesos de comunicación celular permiten a las células desarrollar una acción coordinada durante la embriogénesis y asimilar de forma coherente las señales recibidas a través del entorno. Algunas de las moléculas ...
Salmerón Sánchez, Manuel; Rico Tortosa, Patricia María; Moratal Pérez, David; Lee, Ted T.; Schwarzbauer, Jean E.; Garcia, Andres J.(Elsevier, 2011)
Fibronectin (FN) is a ubiquitous extracellular matrix protein (ECM) protein that is organized into fibrillar networks by cells through an integrin-mediated process that involves contractile forces. This assembly allows for ...
[EN] Protein remodeling at the cell material interface is an important phenomenon that should be incorporated into the design of advanced biomaterials for tissue engineering. In this work, we address the relationship between ...
Ballester Beltrán, José; Rico Tortosa, Patricia María; Moratal Pérez, David; Song, Wenlong; Mano, Joao F; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2011)
Protein adsorption and cellular behavior depend strongly on the wettability of substrates. Such studies are scarce for surfaces exhibiting extreme values of contact angles. Fibronectin (FN) adsorption and adhesion of ...
Background: The cell-material interaction is a complex bi-directional and dynamic process that mimics to a certain extent the natural interactions of cells with the extracellular matrix. Cells tend to adhere and rearrange ...
Ballester Beltrán, José(Universitat Politècnica de València, 2015-03-20)
Abstract
While most of the in vitro cultures are carried out on bi-dimensional (2D)
substrates, most of the in vivo extracellular matrices are threedimensional
(3D). Consequently cells behave differently on 2 ...
[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...
Rodríguez Díaz Caneja, Joaquín(Universitat Politècnica de València, 2019-09-27)
[ES] Este proyecto tiene como objeto el desarrollo de soportes celulares basados en biomateriales poliméricos para su utilización en aplicaciones de Ingeniería Tisular. En concreto, se ha utilizado como técnica de preparación ...
Lozano Juárez, Ana María(Universitat Politècnica de València, 2016-11-03)
[ES] El proyecto final de grado consistirá en la preparación de materiales, films y estructuras tridimensionales (scaffolds), para aplicaciones de regeneración de tejidos (regeneración ósea). Con los materiales preparados, ...
Lenis, J. A.; Rico Tortosa, Patricia María; Gómez Ribelles, José Luís; Pacha-Olivenza, M. A.; González-Martín, M. L.; Bolívar, F. J.(Elsevier BV, 2020-11)
[EN] Biocompatible and antibacterial multi-layer coatings of hydroxyapatite (HA)-Ag/SiO2/TiN/Ti were obtained on the Ti-6Al-4V alloy, by means of the magnetron sputtering technique. During characterization of the coatings, ...
Brizuela Guerra, Nayrim; González-García, Cristina; Llopis, Virginia; Rodriguez-Hernandez, Jose Carlos; Moratal, David; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel(The Royal Society of Chemistry, 2010)
[EN] A family of polymer substrates which consists of a vinyl backbone chain with the side groups
¿COO(CH2)xCH3, with x ¿ 0, 1, 3, 5 was prepared. Substrates with decreasing stiffness, characterised
by the elastic modulus ...