Fraga Timiraos, Ana Belén(Universitat Politècnica de València, 2019-03-04)
[ES] La radiación ultravioleta está asociada a la formación de ciertas lesiones en el ADN que están en el origen del cáncer de piel. Entre las más relevantes se encuentran los daños que se producen en las bases pirimidínicas: ...
Fernández, Benjamín Matthew(Universitat Politècnica de València, 2021-10-29)
[ES] Se está estudiando una nueva clase de grupo protector fotolábil (PPG) basada en el uso de filtro solares. Los PPG son unidades químicas que permiten la protección de grupos funcionales y su posterior fotoliberación. ...
Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(American Chemical Society, 2018-03)
[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
Aparici-Espert, Maria Isabel; Cuquerella Alabort, Maria Consuelo; Paris, Cecilia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2016)
[EN] Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, ...
Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; PARIS, CECILIA GERTRUDIS; Yamaji, Minoru; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2011)
In the present work, three dibenzoylmethane derivatives in their beta-diketo form have been selected to investigate their photophysical and photochemical behavior upon interaction with human serum albumin (HSA). In organic ...
[EN] The photochemistry of the DNA biomacromolecule is an issue of paramount importance as it is part of the etiology of skin cancer development, being ultraviolet sunlight radiation the most relevant environmental carcinogen. ...
Aparici Espert, María Isabel(Universitat Politècnica de València, 2018-07-13)
El objetivo principal de esta tesis es contrastar el papel de dichos compuestos 1,3-dicarbonilicos como agentes que dañan el ADN con respecto a su potencial fotoprotector.
Primero, 5,6-dihidropirimidinas han sido ...
Francés-Monerris, Antonio; Lineros-Rosa, Mauricio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Monari, Antonio(The Royal Society of Chemistry, 2020-04-25)
[EN] The propensity of 5-formyluracil and 5-formylcytosine, i.e. oxidative lesions and epigenetic intermediates, in acting as intrinsic DNA photosensitizers is unraveled by using a combination of molecular modeling, ...
Pinero Santiago, Luis; Garcia, Carmelo; Lhiaubet, Virginie Lyria; Trzcionka, Jéròme; Oyola, Rolando; Torres, Karen; Leguillu, Jaysika; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013-11)
Unwanted photoinduced responses are well-known adverse effects of most promazine drugs, including levomepromazine (LPZ, Levoprome((R)) or Nozinan((R))). This drug is indicated in psychiatry primarily for the treatment of ...
Vendrell Criado, Victoria; Sáez Cases, José Antonio; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013)
The aim of the present work is to determine the influence of C5 substitution on the photophysical properties of 2-thiopyrimidines (2-TPyr). For this purpose, 2-thiouracil, 5-t-butyl-2-thiouracil and 2-thiothymine (TU, BTU ...
Netto Ferreira, Jose Carlos; Lhiaubet ., Virginie Lyria; Bernades, Bauer; Ferreira, Aurelio Baird Buarque; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2014)
[EN] The photophysics and photochemistry of the beta-lapachone derived diphenyldihydrodioxin 3 were investigated using steady-state and time resolved techniques. Laser excitation of 3 leads to the formation of its cation ...
Lizondo Aranda, Paloma(Universitat Politècnica de València, 2022-11-14)
[ES] Los estudios sobre los daños en el ADN se han incrementado en las últimas décadas con el fin de profundizar en su implicación en la aparición del cáncer. Entre el gran número de lesiones del ADN, los aductos de tipo ...
Lineros Rosa, Mauricio(Universitat Politècnica de València, 2021-06-10)
[ES] El espectro de la luz solar está compuesto por una amplia gama de radiaciones electromagnéticas las cuales tienen diferentes impactos sobre la vida en la tierra. Entre ellas, las pertenecientes a la región ultravioleta ...
Bosca Mayans, Francisco; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2011)
Triplet-mediated pyrimidine (Pyr) dimerisation is a key process in photochemical damage to DNA. It may occur in the presence of a photosensitiser, provided that a number of requirements are fulfilled, such as favourable ...
Nuin Pla, Neus Edurne; Pérez-Sala, Dolores; Lhiaubet-Vallet, Virginie Lyria; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(Frontiers Media SA, 2016)
[EN] Triflusal is a platelet aggregation inhibitor chemically related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug. Actually, after oral ...
Nardi, Giacomo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2014-11)
[EN] Imatinib (IMT) is a promising tyrosine kinase inhibitor used in the treatment of some types of human cancer. It constitutes a successful example of rational drug design based on the optimization of the chemical structure ...
Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(Wiley-VCH Verlag, 2013-06-17)
A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These ...
Miró Richart, Paula; Lhiaubet, Virginie Lyria; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(Wiley, 2015-11-16)
A new mechanism of photosensitized formation of thymine (Thy) dimers is proposed, which involves generation of a delocalized triplet excited state as the key step. This is supported by chemical evidence obtained by combining ...
Nardi, Giacomo; Lhiaubet, Virginie Lyria; Leandro García, Paula; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011)
In this work, rosuvastatin has been used to gain insight into the molecular basis of statin photosensitization. This lipid-lowering drug, also known as ¿superstatin¿, contains a 2-vinylbiphenyl-like moiety and has been ...
Marín Melchor, Mireia(Universitat Politècnica de València, 2013-02-20)
La fotoquímica supramolecular es una herramienta muy utilizada para controlar la selectividad, la reactividad y el avance de las reacciones químicas. Con ella se aprovecha la estructura tridimensional del anfitrión para ...