[EN] Silica mesoporous supports (SMSs) have a large specific surface area and volume and are particularly exciting vehicles for delivery applications. Such container-like structures can be loaded with numerous different ...
[EN] We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved ...
Aznar Gimeno, Elena; Villalonga, Reynaldo; Giménez Morales, Cristina; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Díez, Paula; Pingarrón, José M.; Amoros del Toro, Pedro(Royal Society of Chemistry, 2013-05-15)
[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.
Sendra, Luis; Miguel, Antonio; Navarro-Plaza, M. Carmen; Herrero, María José; de la Higuera, José; Cháfer-Pericás, Consuelo; Aznar, Elena; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Rojas, Luis Alfonso; Alemany, Ramón; Aliño, Salvador F.(MDPI AG, 2020-06)
[EN] Oncolytic adenoviruses are a therapeutic alternative to treat cancer based on their ability to replicate selectively in tumor cells. However, their use is limited mainly by the neutralizing antibody (Nab) immune ...
Hernández-Montoto, Andy; Montes-Robles, Roberto; Samadi, Akbar; Gorbe, Mónica; Terrés-Haro, José Manuel; Cao Milán, Roberto; Aznar, Elena; Ibáñez Civera, Francisco Javier; Masot Peris, Rafael; Marcos Martínez, María Dolores; Orzáez, Mar; Sancenón Galarza, Félix; Oddershede, L.B.; Martínez-Máñez, Ramón(American Chemical Society, 2018-08)
[EN] Herein, a novel drug photorelease system based on gold nanostars (AuNSts), coated with a mesoporous silica shell and capped with paraffin as thermosensitive molecular gate, is reported. Direct measurements of the ...
El Sayed Shehata Nasr, Sameh; Giménez Morales, Cristina; Aznar Gimeno, Elena; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Licchelli, Maurizio(Royal Society of Chemistry, 2015)
[EN] Mesoporous silica nanoparticles loaded with safranin O and capped with disulfide-containing oligo(ethylene glycol) chains were used for the selective and sensitive fluorimetric detection of glutathione.
[EN] We report herein the design a hybrid material for the recognition of Ochratoxin A (OTA) by using an aptamer gated-material able to release electroactive species, which can be measured using differential pulse voltammetry. ...
[EN] Biomedical applications based on the magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) may be altered by the mechanical attachment or cellular uptake of these nanoparticles. When nanoparticles ...
Ribes, Àngela; Sánchez-Cabezas, Santiago; Hernández-Montoto, Andy; Villaescusa Alonso, Luis Angel; Aznar, Elena; Martínez-Máñez, Ramón; Marcos Martínez, María Dolores; López-Tendero, María José; Pradas, Sarai; Cuenca-Bustos, Alejandro(MDPI AG, 2020-02-01)
[EN] The addition of light ceramic particles to bulk technological materials as reinforcement to improve their mechanical properties has attracted increasing interest in the last years. The metal matrix composites obtained ...
[EN] Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to ...
Bhat, Ravishankar; García, I.; Aznar, Elena; Arnáiz, B.; Martínez-Bisbal, M.Carmen; Liz-Marzán, L.M.; Penadés, S.; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2018)
[EN] Gated mesoporous silica nanoparticles can deliver payload upon the application of a predefined stimulus, and therefore are promising drug delivery systems. Despite their important role, relatively low emphasis has ...
[EN] An increase of bone diseases incidence has boosted the study of ceramic biomaterials as potential osteo-inductive scaffolds. In particular, mesoporous bioactive glasses have demonstrated to possess a broad application ...
[EN] We present herein the use of nanoporous anodic alumina (NAA) as a suitable support to implement
molecular gates for sensing applications. In our design, a NAA support is loaded with a fluorescent
reporter (rhodamine ...
[EN] Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone ...
Ultimo, Amelia; De La Torre-Paredes, Cristina; Giménez, Cristina; Aznar, Elena; Coll, Carmen; Marcos Martínez, María Dolores; Murguía, Jose R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(The Royal Society of Chemistry, 2020-07-07)
[EN] Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)(IFN)) is loaded with 9-cis-retinoic acid and capped with ...
Diez, Paula; Sanchez, Alfredo; De la Torre Paredes, Cristina; Gamella, Maria; Martínez-Ruíz, Paloma; Aznar, Elena; Martínez-Máñez, Ramón; Pingarron, José M.; Villalonga, Reynaldo(American Chemical Society, 2016-03-30)
We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous ...
[EN] One appealing concept in the field of hybrid materials is related to the design of gated materials. These materials are prepared in such a way that the release of chemical or biochemical species from voids of porous ...
Poyatos-Racionero, Elisa; Pérez-Esteve, Édgar; Marcos Martínez, María Dolores; Barat Baviera, José Manuel; Martínez-Máñez, Ramón; Aznar, Elena; Bernardos Bau, Andrea(John Wiley & Sons, 2019-08-26)
[EN] A new delivery microdevice, based on hydrophobic oleic acid¿capped mesoporous silica particles and able to payload release in the presence of surfactants, has been developed. The oleic acid functionalization confers ...
[EN] Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C. auris is highly desired; nevertheless, ...