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Browsing by Author "Villalonga, Reynaldo"

Now showing items 1-13 of 13

A 1-to-2 demultiplexer hybrid nanocarrier for cargo delivery and activation

de Luis-Fernández, Beatriz; García-Fernández, Alba; Llopis-Lorente, Antoni; Villalonga, Reynaldo; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (The Royal Society of Chemistry, 2020-09-07)

[EN] A biocomputing strategy implemented in hybrid nanocarriers for controlled cargo delivery is described. The nanodevice consists of enzyme-functionalized Janus Au-mesoporous silica nanoparticles, which behave as an ...
A Versatile New Paradigm for the Design of Optical Nanosensors Based on Enzyme-Mediated Detachment of Labeled Reporters: The Example of Urea Detection

Llopis-Lorente, Antoni; VILLALONGA, REYNALDO; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (John Wiley & Sons, 2019-03-07)

[EN] Here, a new bio-inspired nanoarchitectonics approach for the design of optical probes is presented. It is based on nanodevices that combine 1) an enzymatic receptor subunit, 2) a signaling subunit (consisting of a ...
An enzyme-controlled Janus nanomachine for on-command dual and sequential release

Pérez-Calabuig, Ana M.; Diez-Sánchez, Paula; Martínez-Ruiz, Paloma; Martínez-Máñez, Ramón; Sánchez, Alfredo; Villalonga, Reynaldo (The Royal Society of Chemistry, 2020-06-14)

[EN] A novel nanomachine for dual and sequential delivery of two different compounds was developed by grafting a thiol group and a pH sensitive beta-cyclodextrin-based gate-like ensemble on acetylcholinesterase-modified ...
An Interactive Model of Communication between Abiotic Nanodevices and Microorganisms

de Luis-Fernández, Beatriz; Llopis-Lorente, Antoni; Rincón, Paola; Gadea Vacas, José; Sancenón Galarza, Félix; Aznar, Elena; Villalonga, Reynaldo; Murguía, Jose R.; Martínez-Máñez, Ramón (John Wiley & Sons, 2019-10-14)

[EN] The construction of communication models at the micro¿/nanoscale involving abiotic nanodevices and living organisms has the potential to open a wide range of applications in biomedical and communication technologies. ...
Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

Llopis-Lorente, Antoni; de Luis-Fernández, Beatriz; García-Fernández, Alba; Diez, Paula; Sánchez, Alfredo; Marcos Martínez, María Dolores; Villalonga, Reynaldo; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (The Royal Society of Chemistry, 2017)

[EN] We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the ...
Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles

Llopis-Lorente, Antoni; Díez, Paula; De La Torre-Paredes, Cristina; Sanchez, Alfredo; Sancenón Galarza, Félix; Aznar, Elena; Marcos Martínez, María Dolores; Martínez-Ruíz, Paloma; Martínez-Máñez, Ramón; Villalonga, Reynaldo (John Wiley & Sons, 2017-03-28)

[EN] This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and ...
Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles

Villalonga, Reynaldo; Díez, Paula; Sánchez, Alfredo; Aznar, Elena; Martínez-Máñez, Ramón; Pingarrón, J.M. (John Wiley & Sons, 2013-06)

[EN] Novel Janus nanoparticles with Au and mesoporous silica faces on opposite sides were prepared using a Pickering emulsion template with paraffin wax as the oil phase. These anisotropic colloids were employed as integrated ...
Glucose-Responsive Enzyme-Controlled Mesoporous Nanomachine with a Layer-by-Layer Supramolecular Architecture

Jimenez-Falcao, S.; de Luis-Fernández, Beatriz; García-Fernández, Alba; Llopis-Lorente, Antoni; Diez-Sánchez, Paula; Sánchez, Alfredo; Sancenón Galarza, Félix; Martínez-Ruiz, Paloma; Martínez-Máñez, Ramón; Villalonga, Reynaldo (2019-07-25)

[EN] Here we describe the construction of an integrated and pH-sensitive nanomachine with layer-by-layer supramolecular design and enzymatic control for on-command delivery. The nanodevice comprises a first layer of ...
Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles

Aznar Gimeno, Elena; Villalonga, Reynaldo; Giménez Morales, Cristina; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Díez, Paula; Pingarrón, José M.; Amoros del Toro, Pedro (Royal Society of Chemistry, 2013-05-15)

[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.
Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment

Llopis-Lorente, Antoni; de Luis-Fernández, Beatriz; García-Fernández, Alba; Jiménez-Falcao, Sandra; Orzaez, Mar; Sancenón Galarza, Félix; Villalonga, Reynaldo; Martínez-Máñez, Ramón (American Chemical Society, 2018-08)

[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous ...
Interactive models of communication at the nanoscale using nanoparticles that talk to one another

Llopis-Lorente, Antoni; Díez, P.; Sánchez, A.; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Ruiz, Paloma; Villalonga, Reynaldo; Martínez-Máñez, Ramón (Nature Publishing Group, 2017-05-30)

[EN] 'Communication' between abiotic nanoscale chemical systems is an almost-unexplored field with enormous potential. Here we show the design and preparation of a chemical communication system based on enzyme-powered Janus ...
Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery

Diez, Paula; Sanchez, Alfredo; De la Torre Paredes, Cristina; Gamella, Maria; Martínez-Ruíz, Paloma; Aznar, Elena; Martínez-Máñez, Ramón; Pingarron, José M.; Villalonga, Reynaldo (American Chemical Society, 2016-03-30)

We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous ...
Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles

Díez, Paula; Sanchez, Alfredo; Gamella, María; Paloma Martinez-Ruiz; Aznar, Elena; De La Torre, Cristina; Murguía, Jose R.; Martínez-Máñez, Ramón; Villalonga, Reynaldo; Pingarrón, J.M. (American Chemical Society, 2014)

We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based control unit . The system consists of Janus-type ...