Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-05-16)
A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Bosca Mayans, Francisco; Sastre Navarro, German Ignacio; Andreu, José María; Jornet, David; Tormos Faus, Rosa Esperanza; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2015)
[EN] Colchicine (COL) is a bioactive molecule with antitumor properties. When COL binds to tubulin (TU), it inhibits microtubule assembly dynamics. We have investigated COL-TU interactions using laser flash photolysis (LFP) ...
Gustavsson, Thomas; Markovitsi, Dimitra; Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Society of Photo-optical Instrumentation Engineers (SPIE), 2014)
[EN] We report here on a recent time-resolved fluorescence study [1] of the interaction between flurbiprofen (FBP), a chiral non-steroidal anti-inflammatory drug, and human serum albumin (HSA), the main transport protein ...
Müler, Christiane; Bauer, Andreas; Maturi, Mark M.; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel; Bach, Thorsten(American Chemical Society, 2011-09)
Six 2-quinolones, which bear a terminal alkene linked by a three- or four-membered tether to carbon atom C4 of the quinolone, were synthesized and subjected to an intramolecular [2 + 2]-photocycloaddition. The reaction ...
Li, Ming-De; Yan, Zhiping; Zhu, Ruixue; Phillips,David Lee; Aparici-Espert, Maria Isabel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2018-05-02)
[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits ...
Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada(Elsevier, 2016)
Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012)
Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins.
Quantum yield determinations, combined with transient absorption spectroscopic ...
Pavanello, Alice; Blasco-Brusola, Alejandro; Johnston, Peter F.; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa(MDPI AG, 2020-07)
[EN] Four silver phosphate-based materials were successfully synthesized, characterized, and evaluated, together with TiO2, in the photodegradation of synthetic dyes (tartrazine, Orange II, rhodamine, and Brilliant Blue ...
Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Torres, Maria Jose; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-02-10)
Cinacalcet (CIN) is a calcimimetic drug, which contains a naphthalene chromophore and binds almost quantitatively to human serum albumin (HSA). In the present work, the excited states of CIN have been characterized in order ...
Bonancía Roca, Paula(Universitat Politècnica de València, 2013-03-07)
La espectroscopía de absorción transitoria ha resultado ser una
herramienta útil para investigar la formación y desaparición de estados
excitados singlete formados por aniquilación triplete-triplete, tras
sensibilización. ...
Vayá Pérez, Ignacio(Universitat Politècnica de València, 2008-05-07)
Las proteínas son macromoléculas muy abundantes en los organismos vivos. En concreto, la importancia de las proteínas transportadoras (como albúmina sérica humana y bovina) radica en que actúan como vehículo para la ...
Palumbo, Fabrizio(Universitat Politècnica de València, 2014-11-28)
[EN] Cholesterol (Ch) is one of the most important building blocks of cell membranes. It is also one of the
main targets for oxidation via Type I hydrogen abstraction (HA), which leads to a variety of
physiological ...
Andreu Ros, María Inmaculada; Neshchadin, Dmytro; Batchelor, Stephen N.; Miranda Alonso, Miguel Ángel; Gescheidt, Georg(Taylor & Francis, 2013-10-01)
It is shown how chemically induced dynamic nuclear polarisation (CIDNP) spectroscopy is able to efficiently complement electron paramagnetic resonance (EPR), when molecular transformations of free radical pairs are ...
Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Markovitsi, Dimitra; Gustavsson, Thomas; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013)
We report here on the interaction dynamics between flurbiprofen (FBP) and tryptophan (Trp) covalently linked in model dyads and in a complex of FBP with human serum albumin (HSA) probed by time-resolved fluorescence ...
Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2007)
[EN] Fluorescence and laser-flash photolysis measurements have been performed on two pairs of diastereomeric dyads that contain the nonsteroidal anti-inflammatory drug (S)- or (R)-flurbiprofen (FBP) and (S)-tryptophan ...