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Listar por Patrocinador "Medical Research Council, Reino Unido"

Mostrando ítems 1-18 de 18

A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence

Lozano-Torres, Beatriz; Blandez, Juan F.; Galiana, Irene; Lopez-Dominguez, Jose Alberto; Rovira, Miguel; Páez-Ribes, Marta; González-Gualda, Estela; Muñoz-Espín, Daniel; Serrano, Manuel; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (American Chemical Society, 2021-02-09)

[EN] Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. ...
Biochemical- and Biophysical-Induced Barriergenesis in the Blood¿Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models

Schofield, Christina L.; Rodrigo-Navarro, Aleixandre; Dalby, Matthew J.; Van Agtmael, Tom; Salmerón Sánchez, Manuel (Wiley-VCH Verlag GmbH & Co. KGaA, 2021-05)

[EN] Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS-targeting drugs. The importance ...
Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium

Hernández Pérez, Manuel; Fomukong, N.G.; Hellyer, T.; Brown, I.; Dale, J.W. (Blackwell Publishing, 1994-06)

[EN] A highly mobile insertion sequence designated IS1110 was detected in Mycobacterium avium strain LR541 following an observed increase in size of the plasmid pLR20. Genomic libraries of M. avium strains carrying either ...
Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

Zemzemi, Nejib; Bernabeu, Miguel O.; Saiz Rodríguez, Francisco Javier; Cooper, Jonathan; Pathmanathan, Pras; Mirams, Gary R.; Pitt-Francis, Joe; Rodríguez, Blanca (Wiley-Blackwell, 2013-01)

BACKGROUND AND PURPOSE Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to ...
Data-driven discovery of changes in clinical code usage over time: a case-study on changes in cardiovascular disease recording in two English electronic health records databases (2001-2015)

Rockenschaub, Patrick; Nguyen, Vincent; Aldridge, Robert W.; Acosta, Dionisio; Garcia-Gomez, Juan M; Sáez Silvestre, Carlos (BMJ, 2020-02)

[EN] Objectives To demonstrate how data-driven variability methods can be used to identify changes in disease recording in two English electronic health records databases between 2001 and 2015. Design Repeated cross-sectional ...
Electrocardiographic Imaging for Atrial Fibrillation: A Perspective From Computer Models and Animal Experiments to Clinical Value

Salinet, Joao; Molero-Alabau, Rubén; Schlindwein, Fernando S.; Karel, Joël; Rodrigo, Miguel; Rojo-Álvarez, José Luis; Berenfeld, Omer; Climent, Andreu M.; Zenger, Brian; Vanheusden, Frederique; Siles Paredes, Jimena Gabriela; MacLeod, Rob; Atienza, Felipe; Guillem Sánchez, María Salud; Cluitmans, Matthijs; Bonizzi, Pietro (Frontiers Media SA, 2021-04-30)

[EN] Electrocardiographic imaging (ECGI) is a technique to reconstruct non-invasively the electrical activity on the heart surface from body-surface potential recordings and geometric information of the torso and the heart. ...
Exploring Hybrid Parallel Systems for Probabilistic Record Linkage

Boratto, Murilo; Alonso-Jordá, Pedro; Pinto, Clicia; Melo, Pedro; Barreto, Marcos; Denaxas, Spiros (Springer-Verlag, 2019-03)

[EN] Record linkage is a technique widely used to gather data stored in disparate data sources that presumably pertain to the same real world entity. This integration can be done deterministically or probabilistically, ...
Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

Ferreiros-Vidal, Isabel; Carroll, Thomas; Zhang, Tianyi; Lagani, Vincenzo; Ramirez, Ricardo N.; Ing-Simmons, Elizabeth; Gomez-Valades, Alicia G.; Cooper, Lee; Liang, Ziwei; Papoutsoglou, Georgios; Dharmalingam, Gopuraja; Guo, Ya; Tarazona, Sonia; Fernandes, Sunjay J.; Noori, Peri (Public Library of Science, 2019-04)

[EN] The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically ...
Functionalization of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks

Sprott, Mark Robert; Ferrer, GG; Dalby, Matthew J.; Salmerón Sánchez, Manuel; Cantini, Marco (Wiley-VCH, 2019-02-07)

[EN] Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently ...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel (Blackwell Publishing, 2020-04)

[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...
Genomic regions influencing intramuscular fat in divergently selected rabbit lines

Sosa-Madrid, Bolivar Samuel; Hernández, Pilar; Blasco Mateu, Agustín; Haley, Chris S.; Fontanesi, Luca; Santacreu Jerez, María Antonia; Pena, Romi N.; Navarro, Pau; Ibáñez-Escriche, Noelia (Blackwell Publishing, 2020-02)

[EN] Intramuscular fat (IMF) is one of the main meat quality traits for breeding programs in livestock species. The main objective of this study was to identify genomic regions associated with IMF content comparing two ...
Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

Ortiz-Ramón, Rafael; Valdés Hernández, Maria del C.; González-Castro, Victor; Makin, Stephen; Armitage, Paul A.; Aribisala, Benjamin S.; Bastin, Mark E.; Deary, Ian J.; Wardlaw, Joanna M.; Moratal, David (Elsevier, 2019-06)

[EN] Background: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually ...
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men

Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R.; Virtue, Samuel; Watson, Laura P. E.; Murgatroyd, Peter R.; Ambler, Graeme K.; Vidal Puig, Santiago; Chatterjee, Krishna V.; Vidal-Puig, Antonio (American Society for Nutrition, 2017)

[EN] Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold ...
Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms

Romá-Mateo, C; Sacristán-Reviriego, A; Beresford, N.J; Caparrós Martín, José Antonio; Culiañez Macia, Francisco Antonio; Martin, H; Molina, M; Tabernero, L; Pulido, R (Springer Verlag (Germany), 2011-04)

[EN] Dual-specificity phosphatases (DSPs) constitute a large protein tyrosine phosphatase (PTP) family, with examples in distant evolutive phyla. PFA-DSPs (Plant and Fungi Atypical DSPs) are a group of atypical DSPs present ...
Standardizing Single-Frame Phase Singularity Identification Algorithms and Parameters in Phase Mapping During Human Atrial Fibrillation

Li, Xin; Almeida, Tiago P.; Dastagir, Nawshin; Guillem Sánchez, María Salud; Salinet, Joao; Chu, Gavin S.; Stafford, Peter J.; Schlindwein, Fernando S.; Ng, G. André (Frontiers Media SA, 2020-07-21)

[EN] Purpose Recent investigations failed to reproduce the positive rotor-guided ablation outcomes shown by initial studies for treating persistent atrial fibrillation (persAF). Phase singularity (PS) is an important feature ...
Structural connectivity centrality changes mark the path towards Alzheimer's disease

Peraza, Luis R.; Díaz-Parra, Antonio; Kennion, Oliver; Moratal, David; Taylor, John-Paul; Kaiser, Marcus; Bauer, Roman (Elsevier, 2019-01-18)

[EN] Introduction: The pathophysiological process of Alzheimer's disease is thought to begin years before clinical decline, with evidence suggesting prion-like spreading processes of neurofibrillary tangles and amyloid ...
Systematic characterization of the ionic basis of rabbit cellular electrophysiology using two ventricular models

Romero Pérez, Lucia; Carbonell Pascual, Beatriz; Trenor Gomis, Beatriz Ana; Rodríguez, Blanca; Saiz Rodríguez, Francisco Javier; Ferrero De Loma-Osorio, José María (Elsevier, 2011-10)

[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to investigate mechanisms of arrhythmias and excitation-contraction coupling. Our study aims at systematically characterizing ...
You Talking to Me? Cadherin and Integrin Crosstalk in Biomaterial Design

Barcelona-Estaje, Eva; Dalby, Matthew J.; Cantini, Marco; Salmerón Sánchez, Manuel (Wiley-VCH, 2021-03)

[EN] While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination ...