Lozano-Torres, Beatriz; Blandez, Juan F.; Galiana, Irene; Lopez-Dominguez, Jose Alberto; Rovira, Miguel; Páez-Ribes, Marta; González-Gualda, Estela; Muñoz-Espín, Daniel; Serrano, Manuel; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(American Chemical Society, 2021-02-09)
[EN] Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. ...
Schofield, Christina L.; Rodrigo-Navarro, Aleixandre; Dalby, Matthew J.; Van Agtmael, Tom; Salmerón Sánchez, Manuel(Wiley-VCH Verlag GmbH & Co. KGaA, 2021-05)
[EN] Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS-targeting drugs. The importance ...
[EN] A highly mobile insertion sequence designated IS1110 was detected in Mycobacterium avium strain LR541 following an observed increase in size of the plasmid pLR20. Genomic libraries of M. avium strains carrying either ...
Zemzemi, Nejib; Bernabeu, Miguel O.; Saiz Rodríguez, Francisco Javier; Cooper, Jonathan; Pathmanathan, Pras; Mirams, Gary R.; Pitt-Francis, Joe; Rodríguez, Blanca(Wiley-Blackwell, 2013-01)
BACKGROUND AND PURPOSE
Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development.
Here our goal is to demonstrate the ability of computational models to ...
Rockenschaub, Patrick; Nguyen, Vincent; Aldridge, Robert W.; Acosta, Dionisio; Garcia-Gomez, Juan M; Sáez Silvestre, Carlos(BMJ, 2020-02)
[EN] Objectives To demonstrate how data-driven variability methods can be used to identify changes in disease recording in two English electronic health records databases between 2001 and 2015.
Design Repeated cross-sectional ...
Salinet, Joao; Molero-Alabau, Rubén; Schlindwein, Fernando S.; Karel, Joël; Rodrigo, Miguel; Rojo-Álvarez, José Luis; Berenfeld, Omer; Climent, Andreu M.; Zenger, Brian; Vanheusden, Frederique; Siles Paredes, Jimena Gabriela; MacLeod, Rob; Atienza, Felipe; Guillem Sánchez, María Salud; Cluitmans, Matthijs; Bonizzi, Pietro(Frontiers Media SA, 2021-04-30)
[EN] Electrocardiographic imaging (ECGI) is a technique to reconstruct non-invasively the electrical activity on the heart surface from body-surface potential recordings and geometric information of the torso and the heart. ...
[EN] Record linkage is a technique widely used to gather data stored in disparate data sources that presumably pertain to the same real world entity. This integration can be done deterministically or probabilistically, ...
[EN] The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically ...
Sprott, Mark Robert; Gallego-Ferrer, Gloria; Dalby, Matthew J.; Salmerón Sánchez, Manuel; Cantini, Marco(Wiley-VCH, 2019-02-07)
[EN] Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently ...
González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel(Blackwell Publishing, 2020-04)
[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...
[EN] Intramuscular fat (IMF) is one of the main meat quality traits for breeding programs in livestock species. The main objective of this study was to identify genomic regions associated with IMF content comparing two ...
Ortiz-Ramón, Rafael; Valdés Hernández, Maria del C.; González-Castro, Victor; Makin, Stephen; Armitage, Paul A.; Aribisala, Benjamin S.; Bastin, Mark E.; Deary, Ian J.; Wardlaw, Joanna M.; Moratal, David(Elsevier, 2019-06)
[EN] Background: The differential quantification of brain atrophy, white matter hyperintensities (WMH) and stroke lesions is important in studies of stroke and dementia. However, the presence of stroke lesions is usually ...
Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R.; Virtue, Samuel; Watson, Laura P. E.; Murgatroyd, Peter R.; Ambler, Graeme K.; Vidal Puig, Santiago; Chatterjee, Krishna V.; Vidal-Puig, Antonio(American Society for Nutrition, 2017)
[EN] Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold ...
Romá-Mateo, C; Sacristán-Reviriego, A; Beresford, N.J; Caparrós Martín, José Antonio; Culiañez Macia, Francisco Antonio; Martin, H; Molina, M; Tabernero, L; Pulido, R(Springer Verlag (Germany), 2011-04)
[EN] Dual-specificity phosphatases (DSPs) constitute a large protein tyrosine phosphatase (PTP) family, with examples in distant evolutive phyla. PFA-DSPs (Plant and Fungi Atypical DSPs) are a group of atypical DSPs present ...
Li, Xin; Almeida, Tiago P.; Dastagir, Nawshin; Guillem Sánchez, María Salud; Salinet, Joao; Chu, Gavin S.; Stafford, Peter J.; Schlindwein, Fernando S.; Ng, G. André(Frontiers Media SA, 2020-07-21)
[EN] Purpose Recent investigations failed to reproduce the positive rotor-guided ablation outcomes shown by initial studies for treating persistent atrial fibrillation (persAF). Phase singularity (PS) is an important feature ...
[EN] Introduction: The pathophysiological process of Alzheimer's disease is thought to begin years before clinical decline, with evidence suggesting prion-like spreading processes of neurofibrillary tangles and amyloid ...
Romero Pérez, Lucia; Carbonell Pascual, Beatriz; Trenor Gomis, Beatriz Ana; Rodríguez, Blanca; Saiz Rodríguez, Francisco Javier; Ferrero De Loma-Osorio, José María(Elsevier, 2011-10)
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to investigate mechanisms of arrhythmias and excitation-contraction coupling. Our study aims at systematically characterizing ...
[EN] While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination ...